Abstract Delivery of hydrophilic small molecule therapeutics by traditional drug delivery systems is challenging. Herein. we have used the specific interaction between DNA aptamers and drugs to create simple and effective drug depot systems. The specific binding of a phosphorothioate-modified aptamer to drugs formed non-covalent aptamer/drug complexes. https://safeersappliancers.shop/product-category/samsung-rf56m9540sr-family-hub-91cm-frost-free-american-fridge-freezer/